A Likelihood-Based Approach for Missing Genotype Data
نویسندگان
چکیده
منابع مشابه
A Likelihood-Based Approach for Missing Genotype Data.
Missing genotype data in a candidate gene association study can make it difficult to model the effects of multiple genetic variants simultaneously. In particular, when regression models are used to model phenotype as a function of SNP genotypes in several different genes, the most common approach is a complete case analysis, in which only individuals with no missing genotypes are included. But ...
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The model-based approach to inference from multivariate data with missing values is reviewed. Regression prediction is most useful when the covariates are predictive of the missing values and the probability of being missing, and in these circumstances predictions are particularly sensitive to model misspecification. The use of penalized splines of the propensity score is proposed to yield robu...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2010
ISSN: 1423-0062,0001-5652
DOI: 10.1159/000273732